我引用一篇2008年的Journal of Drugs in Dermatology裡面的一篇paper
Parabens, including methylparaben, butylparaben, isobutylparaben, and their metabolite, p-hydroxybenzoic acid, have been extensively used in skin care, cosmetics, foods, and pharmaceutical agents as antimicrobial preservatives for many years. Published reports have emerged in recent years implicating parabens as potential carcinogens in breast cancer, uterine cancer, and most recently, skin cancer.
In summary, a body of published research is accumulating regarding the toxicity of parabens and their metabolites in several organs including breast, uterus and skin. The potential for carcinogenesis must continue to be rigorously analyzed so that alternative forms of nontoxic preservatives may serve as their replacement in foods, pharmaceuticals, cosmetics, and skin care products.